IgG4 antibody

IgG4-related disease (IgG4-RD) is a chronic autoimmune mediated inflammatory, fibrotic disease of unknown origin, which was first described by scholars in the autoimmune pancreatitis (autoimmune pancreatitis, The relationship between AIP and IgG4 positive plasma cells was proposed. In 2003, Kamisawa et al. found that IgG4+ plasma cells not only existed in the pancreas, but also in the bile duct, gastrointestinal mucosa, salivate glands and lymph nodes in AIP patients, thus recognizing that IGG4-RD isa systemic disease and introducing the concept of systemic disease of IgG4 for the first time. Autoimmun Rev magazine officially named it IgG4-RD in 2010. Igg4-rd is characterized by extensive proliferation, infiltration, sclerosis and fibrosis of IgG4+ lymphocytes in tissues and organs, with or without elevated serum IgG4 levels, and can involve multiple organs or systems, causing organ enlargement and tissue destruction. It is manifested as AIP, sclerosing salivary adenitis, inflammatory pseudotumor of liver and breast, retroperitoneal fibrosis, Mikulich disease, etc.

A single IgG4 antibody provided by Abgree, due to its high specificity, can be used in latex to enhance immune turbidity.