类风湿因子RF抗原

货号：R7059

简介：
Rheumatoid factors are defined as autoantibodies reactive with the Fc part of IgG antibodies. Although the classical Waaler-Rose assay depends mainly on IgM antibodies, RF activity can be found in virtually any class of immunoglobulins. The occurrence of IgA-, IgG- as well as IgM-rheumatoid factors is widely established. The IgM-rheumatoid factor consists of five subunits of approximately 185 000 Daltons joined by a disulfide, forming a pentamer . In addition, IgA-rheumatoid factor consists of two identical subunits, forming a polymeric structure varying between 160 000 and 1000 000 Daltons. IgG-rheumatoid factor is in fact monomeric, however, complex formations with other IgG-rheumatoid factor molecules as well as with other IgG antibodies are found . Rheumatoid factors of patients suffering from rheumatoid arthritis react with IgG of various species . Rheumatoid factors react with various epitopes as represented in the different allotypic subgroups and can be found in some animals also.