雌二醇（E2）抗原

货号：E7046

简介：
The estradiol present in breast tissue is synthesized in three sites: the ovary, extraglandular tissues, and the breast itself. Direct glandular secretion by the ovary results in delivery of estradiol to the breast through an endocrine mechanism in premenopausal women. After the menopause, extraglandular production of estrogen from ovarian and adrenal androgens in fat and muscle provides the second source of estradiol. Third, the breast itself can synthesize estradiol via aromatization of androgens to estrogens or cleavage of estrone sulfate to free estrone via the enzyme sulfatase. Estradiol acts through paracrine, autocrine, and intracrine mechanisms on cells in the breast. Several factors regulate in situ estradiol synthesis but the most important is the degree of obesity, which increases the amount of aromatase in breast and consequently estradiol production