甲状腺过氧化物酶（TPO）抗体

货号：grTP01

简介：
Thyroid peroxidase (TPO) is a key enzyme in thyroid hormone biosynthesis. It catalyzes both iodination and coupling of iodotyrosine residues in TG. Human TPO is located on chromosome 2p25, with 17 exons. The mRNA is about 3 kb encoding a thyroid-specific glycosylated hemoprotein of 110 kDa bound at the apical membrane of thyrocytes. The majority of patients with congenital hypothyroidism have defects in the synthesis or iodination of TG that are attributable to TPO deficiency. Subnormal or absence of TPO activities results in thyroid iodide organification giving rise to goitrous congenital hypothyroidism. Total iodide organification defect (TIOD) is inherited in an autosomal recessive mode.