Feb 07, 2023

IgG4-related disease (IgG4-RD) is a chronic autoimmune mediated inflammatory, fibrotic disease of unknown origin, which was first described by scholars in the autoimmune pancreatitis (autoimmune pancreatitis, The relationship between AIP and IgG4 positive plasma cells was proposed. In 2003, Kamisawa et al. found that IgG4+ plasma cells not only existed in the pancreas, but also in the bile duct, gastrointestinal mucosa, salivate glands and lymph nodes in AIP patients, thus recognizing that IGG4-RD isa systemic disease and introducing the concept of systemic disease of IgG4 for the first time. Autoimmun Rev magazine officially named it IgG4-RD in 2010. Igg4-rd is characterized by extensive proliferation, infiltration, sclerosis and fibrosis of IgG4+ lymphocytes in tissues and organs, with or without elevated serum IgG4 levels, and can involve multiple organs or systems, causing organ enlargement and tissue destruction. It is manifested as AIP, sclerosing salivary adenitis, inflammatory pseudotumor of liver and breast, retroperitoneal fibrosis, Mikulich disease, etc.

Feb 07, 2023

In liver cells, prothrombin precursors are modified by vitamin K(Vit K) -dependent gamma-glutamylcarboxylase to synthesize normal prothrombin, in which all 10 glutamic acid (Glu) residues in the n-terminal domain are converted to gamma-carboxylated glutamic acid residues (Gla). If Vit K is deficient or antagonized, glutamic acid residues fail to fully carboxylate thrombin, abnormal prothrombin (PIVKA-II), also known as des-γ-carboxy-prothrombin (DCP), is formed. Due to the number and location of uncarboxylated glutamic acid residues, abnormal prothrombin will show a diversity of structure and species. It is widely believed that the production of PIVKA-II is mainly related to the decreased activity of gamma-glutacylcarboxylase, the deficiency of Vit K or the dysfunction of metabolic utilization.

Feb 07, 2023

Fluorescein isothiocyanate (FITC) is a small molecule hapten that is commonly used as a fluorescent probe to label protein and nucleic acid molecules and to trace polysaccharides and drugs. The stable properties of FITCs and the ability of a single anti-FITC antibody to bind to 3-4 FITC molecules at the same time enable the use of the FitC-anti-FitC system through immunoassay to improve the sensitivity of antigen-antibody responses. Anti-fitc antibodies have been widely used in immunoassay, nucleic acid hybridization, immunospeckle technique and immunohistochemistry.

Feb 07, 2023

Troponin (Tn) is a major regulator of muscle tissue contraction and is composed of three subtypes: troponin C (TnC), troponin T (TnT), and troponin I (TnI). Troponin I is divided into three subtypes: fast skeletal muscle subtype (fTnI), slow skeletal muscle subtype (sTnI) and myocardial subtype (cTnI). cTnI has a molecular weight of 24KDa, and cTn exists in cardiomyocytes in the form of CTNi-C-T complex and free cTnI.

Nov 01, 2022

Heterophilic Blocking Reagent，Antibody blocker, Active blocker, HBR

Nov 01, 2022

BNP antibody, Mouse anti-human BNP antibody, Brain natriuretic peptide Antibody

Nov 01, 2022

 RBP antibody, RBP polyclonal antibody, RBP4 polyclonal Antibody

Nov 01, 2022

Interleukin-6 antibody, Mouse anti-human IL-6 antibody, IL-6 antibody, IL-6 mab

Nov 01, 2022

The immunoturbidimetric reagent developed by Abgree Company with CRP antibody showed a good correlation with a well-known Japanese reagent manufacturer within the linear range of 0.1-320mg/L. At the same time, the CRP antibody of Abgree company was compared with the mainstream reagent in the market on the immunochromatography platform, and the linearity was 0.5-200mg/L, showing a good correlation.

May 27, 2022

Glycated hemoglobin (GHb) is the product of the combination of hemoglobin in red blood cells and sugars in serum. Abgree provides optimized glycosylated hemoglobin antibodies, which can be better used in immunochromatography and latex-enhanced immunoturbidimetry, etc.

May 27, 2022

Abgree provides supporting myoglobin raw materials. The prokaryotic expression of myoglobin has stable performance and good specificity, and is suitable for the preparation of standards and immunogens. Paired myoglobin antibodies are better used in chemiluminescence and immunochromatography platforms.

May 27, 2022

The CRISPR-Cas system, derived from the adaptive immune mechanism of prokaryotes, quickly stands out from many competitive gene editing technologies due to its high specificity, strong developability,...